• PMID: 17335817
• Gene Name: IL1B
• Condition: Associated with sperm pathology
• Association: Associated
• Population size: 562
• Population details: 562 (127 normozoospermic and 435 non-normozoospermic men)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Associated with sperm pathology

A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans

Bentz EK, Hefler LA, Denschlag D, Pietrowski D, Buerkle B, Tempfer CB.

In a prospective case-control study of 127 normozoospermic and 435 non-normozoospermic Caucasian men, the genotype frequencies of a polymorphism of the interleukin-1 beta gene (IL-1beta Taq C-->T) were statistically significantly different between groups (homozygous wild-type C/C [57%], heterozygous C/T [42%], and homozygous mutant T/T [1%] vs. C/C [57%], C/T [36%], T/T [7%] for normozoospermic and non-normozoospermic men, respectively; odds ratio, 4.8; 95% confidence interval, 1.13 to 20.28). This association was restricted to men with the oligoasthenoteratozoospermia (OAT) syndrome. We conclude that the investigated polymorphism is associated with sperm pathology in Caucasians. FAU - Bentz, Eva-Katrin AU - Bentz EK AD - Departments of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria. eva-katrin.bentz@meduniwien.ac.at FAU - Hefler, Lukas A AU - Hefler LA FAU - Denschlag, Dominik AU - Denschlag D FAU - Pietrowski, Detlef AU - Pietrowski D FAU - Buerkle, Bernd AU - Buerkle B