• PMID: 17302030
• Gene Name: SPA17
• Condition: Male infertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Sp17
• Other associated phenotypes: Male infertility

[Detection of anti-Sp17 antibodies in infertile patients' serum and its clinical significance]

Zhang CH, Li FQ, Yang AL, Sun W, Miao JW.

OBJECTIVE: To test anti-Sp17 antibodies in the serum of AsAb positive infertile patients, to investigate the proportion of anti-Spl7 antibodies in AsAb and their potential application to the serologic diagnosis of immune infertility and immunocontraception. METHODS: With human recombinant Sp17 as the antigen, the ELISA method was used to detect the positive rate, antibody titre and content of anti-Sp17 antibodies in the AsAb positive serum. RESULTS: The positive rate of anti-Sp17 antibodies in the AsAb positive serum was 56.5%, with no significant difference in the gender aspect. The percentage of anti-Sp17 antibodies in AsAb was (10.09 +/-7.45) %, with statistical significance (P <0.05). CONCLUSION: Sp17 is an important sperm antigen. Anti-Sp17 antibodies in the serum can be taken as auxiliary diagnostic index of infertility, and Sp17 is shown to be a potential candidate immunocontraception vaccine. FAU - Zhang, Chun-hua AU - Zhang CH AD - PLA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. zch198028@163.com FAU - Li, Fang-qiu AU - Li FQ FAU - Yang, Ai-long AU - Yang AL FAU - Sun, Wei AU - Sun W