• PMID: 17296188
• Gene Name: IZUMO1
• Condition: Male infertility, severe oligozoospermia and/or athenozoospermia, fertilization failure
• Association: Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients.
• Population size: 25
• Population details: 25 (12 infertile patients with fertilization failure, 13 male infertile patients with severe oligozoospermia and/or athenozoospermia)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility, severe oligozoospermia and/or athenozoospermia, fertilization failure

Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients

Hayasaka S, Terada Y, Inoue N, Okabe M, Yaegashi N, Okamura K.

Recently, the immunoglobulin superfamily protein IZUMO on the sperm surface was identified as being essential for sperm-egg fusion. Although we examined the expression of IZUMO on sperm of 13 male infertile patients with severe oligozoospermia and/or athenozoospermia and 12 infertile patients with fertilization failure in previous conventional IVF to determine whether it is varied in infertility patients, we could not identify any patients with IZUMO negative by immunocytochemistry. FAU - Hayasaka, Shinichi AU - Hayasaka S AD - Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Miyagi, Japan. FAU - Terada, Yukihiro AU - Terada Y FAU - Inoue, Naokazu AU - Inoue N FAU - Okabe, Masaru AU - Okabe M FAU - Yaegashi, Nobuo AU - Yaegashi N