• PMID: 16759931
• Gene Name: TPX1
• Condition: Spermatogenic arrest, male infertility, oligoasthenoteratospermia syndrome
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: TPX1
• Other associated phenotypes: Spermatogenic arrest, male infertility, oligoasthenoteratospermia syndrome

Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility

Du Y, Huang X, Li J, Hu Y, Zhou Z, Sha J.

Human testis specific protein 1 (TPX1) exists in the cytomembrane and cytoplasm of spermatogenic cells from pachytene spermatocytes to elongated spermtids, including pachytene spermatocytes, round spermtids and elongated spermtids. It is localized in the connecting piece, the flagellum, and the acrosome of mature human spermatozoa. The protein level and localization of TPX1 were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome. FAU - Du, Yong AU - Du Y AD - Department of Histology and Embryology, Nanjing Medical University, Nanjing, People's Republic of China. FAU - Huang, Xiaoyan AU - Huang X FAU - Li, Jianmin AU - Li J FAU - Hu, Yanqiu AU - Hu Y FAU - Zhou, Zuomin AU - Zhou Z