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PMID 16728350
Gene Name ACE
Condition Varicocele related infertility
Association Associated
Population size 42
Population details 42 (31 infertile patients who underwent variococelectomy, 11 fertile control subjects underwent left inguinal herniorraphy)
Sex Male
Infertility type Male infertility
Associated genes ACE
Other associated phenotypes Varicocele related infertility


Somatic angiotensin converting enzyme in varicocele

Asci R, Sarikaya S, Buyukalpelli R, Yilmaz A, Bedir A.

The ACE is found as two isozymes in the body. A somatic isozyme found in blood and several other tissues, and a testis-specific isozyme found only in developing spermatids and mature sperm. In this study, we investigated the ACE activity in left spermatic vein blood samples of infertile patients with varicocele and its correlation to spermatologic parameters. The somatic ACE activities were determined in the peripheral and left spermatic vein blood samples from 31 infertile patients who underwent variococelectomy, and 11 fertile control subjects underwent left inguinal herniorraphy. The somatic ACE activity was measured by kinetic spectrophotometric assay. Semen analyses were performed according to WHO guidelines. The mean somatic ACE activities of peripheral and left spermatic veins of the varicocele group were 60.3 +/- 23.0 and 60.2 +/- 23.2 U/L, respectively. In control group, peripheral and left spermatic vein ACE activities were found as 56.8 +/- 17.1 and 56.5 +/- 15.5 U/L, respectively. There was no significant difference between the ACE activity in peripheral and left spermatic vein blood sample from the varicocele and control group. There was no statistically significant correlation between the spermatologic parameters and ACE activities in the spermatic and peripheral vein in both of varicocele and control groups. As a result, it may be suggested that the somatic ACE has no causative role in pathophysiology of varicocele and varicocele related infertility. FAU - Asci, R AU - Asci R AD - Department of Urology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. rasci@omu.edu.tr FAU - Sarikaya, S AU - Sarikaya S FAU - Buyukalpelli, R AU - Buyukalpelli R FAU - Yilmaz, A AU - Yilmaz A