• PMID: 16683572
• Gene Name: NOS
• Condition: Male infertility
• Association: Associated
• Population size: 80
• Population details: 80 (40 infertile patients with positive AsAb in seminal plasma as experimental group, 40 fertile men as control group)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: NOS, SOD
• Other associated phenotypes: Male infertility

[Study of the changes of acrosomal enzyme and nitric oxide synthase, superoxide dismutase of infertile patients with positive antisperm antibody in seminal plasma]

Zhang HF, Li JZ, Zhang CY.

OBJECTIVE: To study the impacts of positive antisperm antibody (AsAb) in seminal plasma on acrosomal enzyme activity, nitric oxide synthase (NOS) and superoxide dismutase (SOD) levels of spermatozoa. METHODS: Swatch from 40 infertile patients with positive AsAb in seminal plasma as experimental group, and 40 fertile men as control group. Acrosomal enzyme activity was detected by the BAEE/ADH unitive method, NOS was detected by the redoxreaction assay, and SOD level was measured xanthine oxidase method. RESULTS: Compared with control group, acrosomal enzyme activity of spermatozoa of experimental group was significantly decreased (P <0.01), NOS activity was apparently increased (P < 0.01), and SOD level in seminal plasma was markedly decreased (P<0.01). CONCLUSION: It may be possible that the positive AsAb in seminal plasma beget infertility through the changes of acrosomal enzyme of spermatozoa, SOD and NOS activities in seminal plasma. FAU - Zhang, Hai-feng AU - Zhang HF AD - Department of Urology, the Second Hospital of Harbin Medical University, Heilongjiang, China. zhanghaifenghrb@yahoo.com.cn FAU - Li, Jian-zhong AU - Li JZ