• PMID: 1659252
• Gene Name: ACE
• Condition: Spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: ACE
• Other associated phenotypes: Spermatogenesis

Angiotensin-converting enzyme and other peptidolytic enzymes in human semen and relations to its spermatologic parameters

Siems WE, Heder G, Hilse H, Baeger I, Engel S, Jentzsch KD.

Angiotensin-converting enzyme (ACE) and other enzymes of the renin-angiotensin system (RAS) occur in human semen in high activities. In contrast to bull ejaculates, not all zinc-dependent metallopeptidases are found to be in close correlation to the microscopically determined semen parameters; such a relationship was established only partly for the ACE. On the other hand, the RAS-dependent spermatozoa-bound enzymes, inclusive ACE, uniformly show negative correlations to the spermatologic parameters of human semen. These results, for the first time, point to different functions of the sperm-cell-bound (testicular) and of the seminal plasma (pulmonary) ACE activities. FAU - Siems, W E AU - Siems WE AD - Institute of Drug Research, Berlin, Germany. FAU - Heder, G AU - Heder G FAU - Hilse, H AU - Hilse H FAU - Baeger, I AU - Baeger I FAU - Engel, S AU - Engel S