• PMID: 16580401
• Gene Name: DAZ2
• Condition: Infertility
• Association: The study concludes that patterns and distribution of DAZ copy deletions in Chinese men and demonstrate that the deletions of the entire DAZ gene or the DAZ1/DAZ2 cluster are associated with impaired spermatogenesis
• Mutation: AZFc deletions (gr/gr deletion)
• Population size: 721
• Population details: 721 (485 patients (267 idiopathic azoospermia, 218oligozoospermia), 236 fertile men)
• Age: 21-37 years
• Sex: Male
• Infertility type: Male infertility
• Associated genes: DAZ1/DAZ3/DAZ4
• Other associated phenotypes: Azo/oligozoospermic

Preliminary study of the relationship between DAZ gene copy deletions and spermatogenic impairment in Chinese men

Yang Y, Xiao C, Zhang S, Zhoucun A, Li X, Zhang S.

Copy deletion screening of DAZ gene family on the Y chromosome in 485 patients with idiopathic azoospermia or oligozoospermia and 236 fertile men revealed that the prevalence of deletion patterns of the entire DAZ gene and DAZ1/DAZ2 gene were significantly higher in the patients than in fertile men. The deletion patterns correlate with spermatogenic impairment in a Chinese population. FAU - Yang, Yuan AU - Yang Y AD - Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. FAU - Xiao, Cuiying AU - Xiao C FAU - Zhang, Sizhong AU - Zhang S FAU - Zhoucun, A AU - Zhoucun A FAU - Li, Xiang AU - Li X