• PMID: 16516155
• Gene Name: TEX101
• Condition: May regulate speramtocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: May regulate speramtocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis

A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis

Teng X, Yang J, Xie Y, Ni Z, Hu R, Shi L, Lin Z, Hu L, Zhao G, Ding X, Kong X.

The urokinase receptor, uPAR, which binds to the urinary-type plasminogen activator, controls matrix degradation in the processes of tissue remodeling, cell migration, and invasion. In the present study, we found a new urokinase receptor gene that encodes a 249-amino acid putative protein. Northern blot analysis showed specific expression in the testis of this gene, which we named the spermatogenesis-related gene (SGRG). In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes. Therefore, we conjecture that SGRG may regulate spermatocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis. Since SGRG is specifically expressed in spermatogonia, it provides an attractive candidate for development of a contraceptive vaccine. FAU - Teng, Xiaokun AU - Teng X AD - School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China. FAU - Yang, Jun AU - Yang J FAU - Xie, Yong AU - Xie Y FAU - Ni, Zumei AU - Ni Z FAU - Hu, Ruiying AU - Hu R FAU - Shi, Lvjie AU - Shi L FAU - Lin, Zhixin AU - Lin Z FAU - Hu, Landian AU - Hu L FAU - Zhao, Guoping AU - Zhao G FAU - Ding, Xiaoyan AU - Ding X