• PMID: 16491269
• Gene Name: DAZ1
• Condition: Infertility
• Association: The studies indicate that deletion of gr/gr–DAZ1/DAZ2 may not be sufficient for spermatogenic impairment in Chinese men
• Mutation: gr/gr–DAZ1/DAZ2 deletion
• Population size: 346
• Population details: 346 normozoospermic
• Age: 23-34
• Sex: Male
• Infertility type: Male infertility
• Associated genes: DAZ2

DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men

Yang Y, Xiao CY, A ZC, Zhang SZ, Li X, Zhang SX.

AIM: To explore the possible effect of the deleted in azoospermia (DAZ) copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c (AZFc) region was analyzed in 346 normozoospermic men. METHODS: Three DAZ single nucleotide variant loci and seven AZFc-specific sequence-tagged sites were examined with polymerase chain reaction (PCR)-restriction fragment length polymorphism and routine PCR. RESULTS: Five (1.4%) of the normozoospermic men were found to have deletion of gr/gr-DAZ1/DAZ2. None of the men were found to have b2/b4-entire DAZ deletion. CONCLUSION: The presence of gr/gr-DAZ1/DAZ2 deletion in five men with normozoospermia suggests that this deletion per se may not be sufficient for spermatogenic impairment in Chinese men. FAU - Yang, Yuan AU - Yang Y AD - Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China. FAU - Xiao, Cui-Ying AU - Xiao CY FAU - A, Zhou-Cun AU - A ZC FAU - Zhang, Si-Zhong AU - Zhang SZ FAU - Li, Xiang AU - Li X