• PMID: 16398361
• Gene Name: AKAP82
• Condition: Asthenospermia
• Association: Associated
• Population size: 68
• Population details: 68 (41 patients with asthenospermia (experimental group), 27 healthy fertile men (control group))
• Sex: Male
• Infertility type: Male infertility
• Associated genes: AKAP82
• Other associated phenotypes: Asthenospermia

[AKAP82 expression in sperm in asthenospermia]

Li Y, Liu JH, Wang T, Ye ZQ.

OBJECTIVE: To study the expression of AKAP82 which was one of A-kinase anchor proteins in sperm in asthenospermia. METHODS: Sperm from 41 patients with asthenospermia (experimental group) and 27 healthy fertile men (control group). Motility parameters were estimated with a computer-assisted semen analysis (CASA) technique. Electrophoretic and immunoblot analysis and indirect immunofluorescence of sperm were assayed in experimental group and control group respectively. RESULTS: Eleven cases in experimental group showed abnormal bands or deletion of normal band in immunoblot analysis, 2 of which were also abnormal in immunofluorescence results, and while only 2 abnormal in the control. A significant difference between experimental and control group was observed (P < 0.05). CONCLUSION: Abnormality of AKAP82 expression in sperm may be one of the etiological factors in asthenospermia. FAU - Li, Yang AU - Li Y AD - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. liyang7365@163.com FAU - Liu, Ji-hong AU - Liu JH FAU - Wang, Tao AU - Wang T