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PMID 16275261
Gene Name DAZ1
Condition Infertility
Association The study concludes that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure
Mutation Deletions and duplications in the DAZ gne cluster
Population size 140
Population details 90 infertile ( 44 azoospermia, 46 severe oligozoospermia), 50 controls
Sex Male
Infertility type Male infertility
Other associated phenotypes azoospermia and severe Oligozoospermia


Copy number of DAZ genes in infertile men

Writzl K, Zorn B, Peterlin B.

The aim of the study was to define the relevance of deletions and duplications within the DAZ gene cluster to male factor infertility in a population of 90 infertile men and a control of 50 fertile men using real-time polymerase chain reaction (PCR). We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure. FAU - Writzl, Karin AU - Writzl K AD - Division of Medical Genetics, University Medical Center, Ljubljana, Slovenia. FAU - Zorn, Branko AU - Zorn B