About Us |
PMID | 16275261 |
Gene Name | DAZ1 |
Condition | Infertility |
Association |
The study concludes that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure |
Mutation | Deletions and duplications in the DAZ gne cluster |
Population size | 140 |
Population details | 90 infertile ( 44 azoospermia, 46 severe oligozoospermia), 50 controls |
Sex | Male |
Infertility type | Male infertility |
Other associated phenotypes |
azoospermia and severe Oligozoospermia |
Copy number of DAZ genes in infertile men Writzl K, Zorn B, Peterlin B. The aim of the study was to define the relevance of deletions and duplications within the DAZ gene cluster to male factor infertility in a population of 90 infertile men and a control of 50 fertile men using real-time polymerase chain reaction (PCR). We conclude that partial deletions of the DAZ genes are associated with oligozoospermia but not with azoospermia; however, an increased number of DAZ genes does not seem to be a statistically significant risk factor for spermatogenic failure. FAU - Writzl, Karin AU - Writzl K AD - Division of Medical Genetics, University Medical Center, Ljubljana, Slovenia. FAU - Zorn, Branko AU - Zorn B |