• PMID: 16169419
• Gene Name: SPO11
• Condition: Male factor infertility
• Association: Associated
• Mutation: SPO11 (E9K, D277E, ?1 insC, 38 T>C (F13S), 271 A>G (M91V))
• Population size: 96
• Population details: 96 patients with male factor infertility (53 Japanese men with nonobstructive azoospermia or oligospermia)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: SPO11
• Other associated phenotypes: Male factor infertility

Screening the SPO11 and EIF5A2 genes in a population of infertile men

Christensen GL, Ivanov IP, Atkins JF, Mielnik A, Schlegel PN, Carrell DT.

Populations of infertile and fertile men were screened for mutations in SPO11 and EIF5A2, two infertility candidate genes. Three heterozygous amino acid changes that might contribute to infertility were identified in the infertile group. FAU - Christensen, Greg L AU - Christensen GL AD - University of Utah School of Medicine, Salt Lake City, Utah, USA. FAU - Ivanov, Ivaylo P AU - Ivanov IP FAU - Atkins, John F AU - Atkins JF FAU - Mielnik, Anna AU - Mielnik A FAU - Schlegel, Peter N AU - Schlegel PN