• PMID: 16081583
• Gene Name: SMYD3
• Condition: May influence transcriptional regulation during spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: May influence transcriptional regulation during spermatogenesis

SMYD3-NY, a novel SMYD3 mRNA transcript variant, may have a role in human spermatogenesis

Zhou Z, Ren X, Huang X, Lu L, Xu M, Yin L, Li J, Sha J.

Identification of genes specifically expressed in adult and fetal testis is important to further our understanding of testis development and function. In this study, a novel SMYD3 transcript variant, termed SMYD3-NY (GenBank Accession No. AY186742), was identified by hybridization of adult and fetal human testis cDNA probes with a human cDNA microarray. SMYD3-NY transcript was expressed at 2.3-fold higher levels in adult human testis than in fetal testis, with a low expression level in human spermatozoa. Bioinformatical analysis showed that SMYD3-NY protein has the SET domain that is involved in histone methyltransferase (HTMase) activity. Southern blotting showed that SMYD3-NY is distributed in several tissues, including testis. In summary, SMYD3-NY is a novel transcript variant of the SMYD3 gene, and SMYD3-NY protein may influence transcriptional regulation during spermatogenesis via HTMase activity. FAU - Zhou, Zuomin AU - Zhou Z AD - Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 210029, People's Republic of China. FAU - Ren, Xuan AU - Ren X FAU - Huang, Xiaoyan AU - Huang X FAU - Lu, Li AU - Lu L FAU - Xu, Min AU - Xu M FAU - Yin, LanLan AU - Yin L FAU - Li, Jianmin AU - Li J