• PMID: 15948408
• Gene Name: FSH
• Condition: Varicocele
• Association: Associated
• Population size: 139
• Population details: 139 infertile patients who underwent varicocelectomy
• Sex: Male
• Infertility type: Male infertility
• Associated genes: FSH
• Other associated phenotypes: Varicocele

[Predictive factors associated with successful varicocele repair a study of 139 infertile men with valicocele]

Kiuchi H, Koga M, Hirai T, Namba Y, Takeyama M, Nishimura K, Tsujimura A, Matsumiya K, Okuyama A.

PURPOSE: To determine pretreatment parameters which predict improvements following varicocele repaire in semen quality. MATERIALS AND METHODS: We retrospectively evaluated a total of 139 infertile patients who underwent varicocelectomy from February 1995 to March 2000. A logistic regression analysis was performed to identify parameters associated with improvements in semen quality. Parameters evaluated included varicocele grade, age, testicular volume, serum testosterone, liteinizing hormone (LH), follicle-stimulating hormone (FSH), preoperative sperm density and sperm motility. RESULTS: Of 139 patients 71 (51.0%) improved sperm concentration and 59 (42.4%) improved sperm motility postoperatively. Overall, median sperm density significantly increased from 10 x 10(6)/ml preoperatively to 30 x 10(6)/ml postoperatively. Sperm motility also significantly increased 33% to 45%. In logistic regression analysis, varicocele grade (odds ratio [OR] = 5.7; 95% confidential interval [CI : 1.9-17), FSH level ([OR] = 0.76; [CI]: 0.60-0.96) and sperm motility ([OR] = 1.03; [CI]: 1.0-1.1) were independent predictive factors for improvement in sperm concentration. CONCLUSION: Varicocelectomy improves sperm concentration and motility. Our data suggest that patients with grade 3 varicocele, low serum FSH level and high sperm motility are more likely to benefit from varicocele repair in sperm concentration. FAU - Kiuchi, Hiroshi AU - Kiuchi H AD - Department of Urology, Osaka Central Hospital. FAU - Koga, Minoru AU - Koga M FAU - Hirai, Toshiaki AU - Hirai T FAU - Namba, Yukiomi AU - Namba Y FAU - Takeyama, Masami AU - Takeyama M FAU - Nishimura, Kenji AU - Nishimura K FAU - Tsujimura, Akira AU - Tsujimura A FAU - Matsumiya, Kiyomi AU - Matsumiya K