• PMID: 15908101
• Gene Name: ADM
• Condition: Sperm motility, male infertility
• Association: These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility.
• Population size: 19
• Population details: 19 obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Sperm motility, male infertility

Adrenomedullin in human male reproductive system

Marinoni E, Di Iorio R, Villaccio B, Vellucci O, Di Netta T, Sessa M, Letizia C, Cosmi EV.

OBJECTIVE: To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters. STUDY DESIGN: Plasma and semen samples (n = 19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52. RESULTS: Mean AM concentration in seminal plasma was 209.4+/-46.6 pg/ml, 8-9-fold higher than in circulating plasma and correlated with sperm motility (r = 0.715, p < 0.01). Endothelial cells of cavernous vessels stained for AM. Intense AM immunostaining was found in germinal cells and in peritubular myocytes and Leydig cells in the testis. CONCLUSIONS: These findings demonstrated for the first time that AM is localized in human male reproductive system. The local secretion of AM suggests that AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility. FAU - Marinoni, Emanuela AU - Marinoni E AD - Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Viale Regina Elena 324, I-00161 Rome, Italy. emanuelamarinoni@hotmail.com FAU - Di Iorio, Romolo AU - Di Iorio R FAU - Villaccio, Barbara AU - Villaccio B FAU - Vellucci, Olga AU - Vellucci O FAU - Di Netta, Tiziana AU - Di Netta T FAU - Sessa, Mariateresa AU - Sessa M FAU - Letizia, Claudio AU - Letizia C