• PMID: 15748601
• Gene Name: PGDS
• Condition: non-obstructive azoospermia
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: PGDS
• Other associated phenotypes: non-obstructive azoospermia

Relationship between lipocalin-type prostaglandin D synthase and alpha-glucosidase in azoospermia seminal plasma

Chen DY, Wang JJ, Huang YF, Zhou KY.

BACKGROUND: [corrected] To determine the correlation of lipocalin-type prostaglandin D synthase (L-PGDS) and alpha-glucosidase in semen. METHODS: We analyzed 68 seminal plasmas for lipocalin-type prostaglandin D synthase (L-PGDS) and alpha-glucosidase, L-PGDS was analyzed by ELISA. The semen donors were categorized in 3 groups: normal, obstructive and non-obstructive azoospermia. We then evaluated their correlation. RESULTS: The difference of L-PGDS concentration (P<0.001) and alpha-glucosidase activity (P<0.001) among the 3 clinical groups was statistically significant. Correlation between L-PGDS concentration and alpha-glucosidase was also statistically significant. L-PGDS concentration correlated positively with alpha-glucosidase activity (r=0.882). CONCLUSIONS: L-PGDS in seminal plasma, like alpha-glucosidase, suggests an obstruction of the seminal ducts and may be a potential marker that may aid in the differential diagnosis of obstructive and non-obstructive azoospermia. FAU - Chen, De-Yu AU - Chen DY AD - College of Life Science, Nanjing Normal University, Nanjing, China; Laboratory of Reproduction and Genetics, JinLing Hospital, Nanjing, China. chendeyu@263.net FAU - Wang, Jun-Jun AU - Wang JJ FAU - Huang, Yu-Feng AU - Huang YF