• PMID: 15147871
• Gene Name: NDEL1
• Condition: Plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules
• Association: Associated
• Sex: Male
• Infertility type: Male infertility

Expression of NUDEL in manchette and its implication in spermatogenesis

Yamaguchi N, Takanezawa Y, Koizumi H, Umezu-Goto M, Aoki J, Arai H.

Nuclear distribution gene E-like product (NUDEL) is a mammal homologue of fungal NUDE and is involved in neuronal migration during brain development. High levels of NUDEL were expressed in murine testis as well as brain. During spermatogenesis, NUDEL was not detected until postnatal day 12 (P12), rising to significant levels at P27. NUDEL was localized predominantly along microtubules of the manchette in elongated spermatids. In maturing spermatids, NUDEL was observed only in the centrosomes, while mature testicular spermatozoa did not show any NUDEL expression. These results suggest that NUDEL plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules. FAU - Yamaguchi, Noritaka AU - Yamaguchi N AD - Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. FAU - Takanezawa, Yasukazu AU - Takanezawa Y FAU - Koizumi, Hiroyuki AU - Koizumi H FAU - Umezu-Goto, Makiko AU - Umezu-Goto M FAU - Aoki, Junken AU - Aoki J