• PMID: 15095338
• Gene Name: DAZ1
• Condition: Infertility
• Association: The study concludes that whenever sperm was available for ICSI cycles in Y-chromosome microdeleted patients, the embryo outcome was comparable to conventional IVF
• Mutation: Y chromosome microdeletions
• Population size: 118
• Population details: 118 infertile
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Azoospermia, Oligozoospermia

Embryo outcome in Y-chromosome microdeleted infertile males after ICSI

Kihaile PE, Kisanga RE, Aoki K, Kumasako Y, Misumi J, Utsunomiya T.

A prospective study involving 118 infertile Japanese couples to assess the embryo outcomes in both azoospermic and oligoasthenoteratoazoospermic (OAT) patients with Y-chromosome microdeletion. The men were divided into two groups; azoospermia (n = 27), and OAT, sperm concentration <5 x 10(6)/ml (n = 91). They were investigated for Y-chromosome microdeletions by a polymerase chain reaction (PCR) amplification of the Y-chromosome-specific sequence tag site (STS). The embryo outcomes of patients found to have Y-microdeletion were determined. The frequency of microdeletion was 8.8% (9) and two had microdeletions distal to DAZ. The mean fertilization rate and the cleavage rate in the eight cycles of both azoospermic and oligospermic patients were 59.3 and 87.5%, respectively. The percentages of grade 1 & 2 embryos, > or =6 cells embryos, and blastocyts were 51.7, 65.6, and 45.3%, respectively. Three pregnancies resulted from the eight cycles (37.5%). CONCLUSION: in Y-chromosome microdeletion cycles in which sperm cells were available for intracytoplasmic sperm injection (ICSI), embryo outcome was comparable to conventional IVF. CI - Copyright 2004 Wiley-Liss, Inc. FAU - Kihaile, Paul E AU - Kihaile PE AD - Oita Medical University, Oita City 879-5593, Japan. kihaile@oita-med.ac.jp FAU - Kisanga, Ramzy E AU - Kisanga RE FAU - Aoki, Kazuo AU - Aoki K FAU - Kumasako, Yoko AU - Kumasako Y FAU - Misumi, Junichi AU - Misumi J