• PMID: 15078889
• Gene Name: ATP2B4
• Condition: Required for sperm motility and male fertility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility

Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility

Schuh K, Cartwright EJ, Jankevics E, Bundschu K, Liebermann J, Williams JC, Armesilla AL, Emerson M, Oceandy D, Knobeloch KP, Neyses L.

Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are infertile due to severely impaired sperm motility. Furthermore, the PMCA inhibitor 5-(and-6)-carboxyeosin diacetate succinimidyl ester reduced sperm motility in wild-type animals, thus mimicking the effects of PMCA4 deficiency on sperm motility and supporting the hypothesis of a pivotal role of the PMCA4 on the regulation of sperm function and intracellular Ca(2+) levels. FAU - Schuh, Kai AU - Schuh K AD - Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany. schuh_k@klinik.uni-wuerzburg.de FAU - Cartwright, Elizabeth J AU - Cartwright EJ FAU - Jankevics, Eriks AU - Jankevics E FAU - Bundschu, Karin AU - Bundschu K FAU - Liebermann, Jürgen AU - Liebermann J FAU - Williams, Judith C AU - Williams JC FAU - Armesilla, Angel L AU - Armesilla AL FAU - Emerson, Michael AU - Emerson M FAU - Oceandy, Delvac AU - Oceandy D FAU - Knobeloch, Klaus-Peter AU - Knobeloch KP