• PMID: 15047941
• Gene Name: CCNA1
• Condition: Assocaited with male sterility
• Association: Associated
• Sex: Male
• Infertility type: Male infertility

Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice

van der Meer T, Chan WY, Palazon LS, Nieduszynski C, Murphy M, Sobczak-Thépot J, Carrington M, Colledge WH.

In higher eukaryotes, the cyclins constitute a family of proteins involved in progression through the cell cycle. The cyclin A1 gene (Ccna1) is expressed during meiosis and is required for spermatogenesis. Targeted disruption of the Ccna1 gene with a LacZ reporter gene has allowed us to study the expression pattern of this gene in more detail. We have confirmed expression in mouse pre-meiotic spermatocytes and also detected expression in the accessory olfactory bulb, hippocampus and amygdala of the adult brain. We have also found that the amount of cyclin A1 protein influences the fertility of male mice and its action is modulated by genetic background. On an outbred genetic background (129S6/SvEv x MF1), Ccna1 (tm1Col) -/- animals are sterile due to spermatogenic arrest prior to the first meiotic division while Ccna1 (tm1Col) +/- mice show reduced sperm production and fertility. This is even more pronounced on an inbred genetic background (129S6/SvEv) where Ccna1 (tm1Col) +/- male mice are sterile due to a severe reduction in the total number of sperm. FAU - van der Meer, Tiffany AU - van der Meer T AD - Department of Physiology, University of Cambridge, Cambridge CB2 3EG, UK. FAU - Chan, W-Y Iris AU - Chan WY FAU - Palazon, Luis S AU - Palazon LS FAU - Nieduszynski, Conrad AU - Nieduszynski C FAU - Murphy, Martin AU - Murphy M FAU - Sobczak-Thépot, Joelle AU - Sobczak-Thépot J FAU - Carrington, Mark AU - Carrington M