• PMID: 14727349
• Gene Name: RAP1A
• Condition: Aspermia
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: RAP1A
• Other associated phenotypes: Aspermia

[A study of aspermia-related genes by genchips and analysis of the RAP1A gene]

Yang B, Gao XK, Wang H, Liu HL, Chen BQ, Yuan JL, Shao GX, Shao C.

OBJECTIVE: To study the differential gene expression profiles between the normal and aspermia human testes by genechips. METHODS: Probes were prepared from mRNA extracted from both normal and aspermia testes and employed on Biostar H-40s genechips to detect the differential gene expression profiles. A distinctly up-regulated gene RAP1A was analyzed by bibliogrphic retrieval. RESULTS: Six hundred and twenty-three differential expressed genes were found, among which the distinctly up-regulated gene RAP1A was closely related to human sperm regulation. CONCLUSIONS: Screening the differential gene expression profiles between the normal and aspermia human testes by genechips can be used in the study of aspermia-related genes. FAU - Yang, Bo AU - Yang B AD - Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. FAU - Gao, Xiao-Kang AU - Gao XK FAU - Wang, He AU - Wang H FAU - Liu, He-Liang AU - Liu HL FAU - Chen, Bao-Qi AU - Chen BQ FAU - Yuan, Jian-Lin AU - Yuan JL FAU - Shao, Guo-Xing AU - Shao GX