• PMID: 14652023
• Gene Name: KISS1R
• Condition: Provides insights into human reproductive syndromes
• Association: Associated
• Sex: Male
• Infertility type: Male infertility

The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

Funes S, Hedrick JA, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, Yang S, Monsma FJ, Gustafson EL.

GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes. FAU - Funes, Sandrine AU - Funes S AD - Functional Genomics Research, Discovery Technologies Department, Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. FAU - Hedrick, Joseph A AU - Hedrick JA FAU - Vassileva, Galya AU - Vassileva G FAU - Markowitz, Lisa AU - Markowitz L FAU - Abbondanzo, Susan AU - Abbondanzo S FAU - Golovko, Andrei AU - Golovko A FAU - Yang, Shijun AU - Yang S FAU - Monsma, Frederick J AU - Monsma FJ