• PMID: 14620284
• Gene Name: FSH
• Condition: Azoospermia
• Association: Associated
• Population size: 50
• Population details: 50 patients undergoing testicular biopsy prior to ICSI
• Sex: Male
• Infertility type: Male infertility
• Associated genes: FSH
• Other associated phenotypes: Azoospermia

Predictive factors for motile sperm recovery using testicular biopsy in nonobstructive azoospermic patients

Souza CA, Cunha Filho JS, Santos D, Gratão A, Freitas FM, Passos EP.

OBJECTIVE: The objective of the present study was to assess the predictive value of hormone values, histological analysis for the finding of motile spermatozoa on testicular biopsy in nonobstructive azoospermia. METHODS: This cross-sectional study assessed serum follicle-stimulating hormone (FSH), luteinizing hormone, prolactin and total testosterone values in 50 patients undergoing testicular biopsy prior to ICSI. P < 0.05 was considered significant. RESULTS: Recovery was successful in 28 cases, and motile spermatozoa were retrieved in 7. Significant differences were detected between presence of motile spermatozoa and absence of spermatozoa in terms of FSH values (P = 0.003, one-way ANOVA). The other variables did not present statistical differences. A receiver operating characteristic curve showed that FSH levels below 17.00 IU/L were predictive of motile spermatozoa recovery. CONCLUSIONS: FSH values can serve as a predictive factor for the recovery of motile spermatozoa using biopsy in azoospermic patients. On the other hand, histological analysis and other hormone values were not helpful in the prediction of motile sperm. FAU - Souza, C A B AU - Souza CA AD - Human Reproduction Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. casouza@via-rs.net FAU - Cunha Filho, J S AU - Cunha Filho JS FAU - Santos, D AU - Santos D FAU - Gratão, A AU - Gratão A FAU - Freitas, F M AU - Freitas FM