• PMID: 12931371
• Gene Name: LHB
• Condition: Azoospermia, Oligospermia
• Association: Associated
• Population size: 150
• Population details: 150 (50 male patients with idiopathic azoospermia, 50 in idiopathic oligospermia and 50 male controls)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: LH, FSH
• Other associated phenotypes: Azoospermia, Oligospermia

[Detection of sexual hormone in semen of patients with idiopathic azoospermia or oligospermia and its significance]

Zhang JR, Yao B, Wang YM, Cui YX, Wang SK, Ge YF, Huang YF.

OBJECTIVES: To detect the sexual hormone level in semen of patients with idiopathic azoospermia and oligospermia, and further analyze the relationship between sexual hormone and idiopathic azoospermia and oligospermia. METHODS: 50 male patients with idiopathic azoospermia, 50 in idiopathic oligospermia and 50 male controls with normal sperm density were selected. The sperm density and sexual hormone in semen were detected respectively by routine semen analysis and chemical luminescence technique. RESULTS: The values of LH were (5.19 +/- 0.67) IU/L and (4.77 +/- 0.68) IU/L, and those of FSH were (1.90 +/- 0.79) IU/L and (2.27 +/- 0.25) IU/L in idiopathic azoospermia and oligospermia respectively, and the values of LH and FSH were (2.19 +/- 0.22) IU/L and (1.61 +/- 0.14) IU/L in normal control group respectively. There were significant differences in the values of LH and FSH between idiopathic azoospermia and normal control group(P < 0.01 or P < 0.05). The values of PRL were (6.25 +/- 0.51) ng/ml and (6.33 +/- 0.34) ng/ml, and those of T were (1.51 +/- 0.12) ng/ml and (1.68 +/- 0.71) ng/ml in idiopathic azoospermia and oligospermia respectively, and the values of PRL and T were (6.36 +/- 0.32) ng/ml and (1.83 +/- 0.09) ng/ml in normal control group respectively. There were no significant difference in the values of PRL between idiopathic azoospermia, oligospermia and normal control group, but there were significant differences of T between idiopathic azoospermia and normal control. Compared with 0.84 +/- 0.20 in normal control, the values of T/LH were 0.35 +/- 0.09 and 0.29 +/- 0.04 in idiopathic oligospermia and azoospermia respectively and there were significant differences(P < 0.05). CONCLUSIONS: The changes of LH, FSH and T values may be one of the reasons that cause the dysfunction of spermatogenesis and sperm maturation in patients with idiopathic azoospermia and oligospermia. The study of semen hormone may lead to new strategies in the treatment to azoospermia and oligospermia. FAU - Zhang, Jin-Rong AU - Zhang JR AD - Laboratory of Reproduction & Genetics, Nanjing General Hospital, Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. FAU - Yao, Bing AU - Yao B FAU - Wang, Yong-Mei AU - Wang YM FAU - Cui, Ying-Xia AU - Cui YX FAU - Wang, Shu-Kui AU - Wang SK FAU - Ge, Yi-Feng AU - Ge YF