• PMID: 12895410
• Gene Name: USP9Y
• Condition: Associated with male germ cell development
• Association: Through de-ubiquitination, USP9Y may stabilizes a specific target protein that is important for male germ cell development
• PMID: 12895410
• Gene Name: USP9Y
• Condition: Associated with male germ cell development
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Associated with male germ cell development

Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome

Lee KH, Song GJ, Kang IS, Kim SW, Paick JS, Chung CH, Rhee K.

Deletions of USP9Y have been observed among infertile males with defective spermatogenesis. Therefore, the gene has been designated as a male infertility gene on the Y chromosome. However, it remains to be determined how male infertility results from deletions of this gene. In order to initiate an investigation into the cellular functions of USP9Y in male germ cell development, in the present study we characterized the enzymatic specificity of USP9Y. Our results show that both USP9Y and Fam, the mouse infertility protein Usp9x, possess a protease activity specific to ubiquitin. These results suggest that, through de-ubiquitination, USP9Y may stabilize a specific target protein that is important for male germ cell development. FAU - Lee, Kyung Ho AU - Lee KH AD - School of Biological Sciences, Seoul National University, Seoul 151-742, Korea. FAU - Song, Gyun Jee AU - Song GJ FAU - Kang, Inn Soo AU - Kang IS FAU - Kim, Soo Woong AU - Kim SW FAU - Paick, Jae-Seung AU - Paick JS FAU - Chung, Chin Ha AU - Chung CH