• PMID: 12749127
• Gene Name: IL-8
• Condition: Leukocytospermia, male infertility
• Association: Associated
• Population size: 42
• Population details: 42 (15 normal donors, 16 infertile men without infection, 11 leukocytospermia)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: IL-8
• Other associated phenotypes: Leukocytospermia, male infertility

[Measurement of the reactive oxygen species and cytokines in the seminal plasma of leukocytospermic patients]

Liu J, Wang YX, Wu YL, Qian XM, Xiang ZQ.

OBJECTIVES: To detect the levels of reactive oxygen species (ROS), superoxide dismutase(SOD) and interleukin 8(IL-8) in seminal plasma of infertile patients, and evaluate the possible relationship between those levels. METHODS: Semen was collected from normal donors (15 cases), infertile men without infection (16 cases), and infertile men with infection (leukocytospermia, 11 cases). The routine analysis of semen was accomplished, and then the levels of IL-8, malondialdehyde (MDA), SOD, and white blood cell (WBC) were examined. The correlative analysis between the level of ROS and other parameters in these populations was made. RESULTS: In leukocytospermic group, the levels of MDA, WBC, and IL-8 were higher than those in the other two groups (P < 0.001). Significantly positive correlation was observed between IL-8 and MDA (r = 0.852, P < 0.001) and between the levels of IL-8 and WBC. CONCLUSIONS: These findings suggest that increased oxidative stress in patients with leukocytospermia may cause the increase of IL-8(r = 0.818, P < 0.01). The increased oxidative stress may be due to defect in ROS scavenging system. FAU - Liu, Jing AU - Liu J AD - Department of Urology, Zhongda Hospital Affiliated to Medical College of Southeast University, Nanjing, Jiangsu 210009, China. FAU - Wang, Yi-Xing AU - Wang YX FAU - Wu, Yu-Lun AU - Wu YL FAU - Qian, Xian-Ming AU - Qian XM