• PMID: 12711554
• Gene Name: TEX14
• Condition: Plays a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Plays a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis

Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis

Wu MH, Rajkovic A, Burns KH, Yan W, Lin YN, Matzuk MM.

To discover germ cell-specific genes, we used in silico subtraction and identified testis expressed gene 14 (Tex14). Mouse Tex14 contains an open reading frame encoding a 1450-amino-acid protein, which shares 64% amino acid identity with the predicted human TEX14 protein. The predicted TEX14 amino acid sequence consists of three ankyrin repeats, a protein kinase domain, and a leucine zipper dimerization motif. Northern blot analysis and in situ hybridization show that Tex14 mRNA is expressed specifically in the testis, with highest levels observed in pachytene, diplotene, and meiotically dividing spermatocytes. Two 5' splice variants of mouse Tex14 were discovered by sequencing 5'-RACE polymerase chain reaction products. TEX14 is predicted to be localized to the nucleus, suggesting that it may play a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis. FAU - Wu, Meng-Hsing AU - Wu MH AD - Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. FAU - Rajkovic, Aleksandar AU - Rajkovic A FAU - Burns, Kathleen H AU - Burns KH FAU - Yan, Wei AU - Yan W FAU - Lin, Yi-Nan AU - Lin YN