• PMID: 12619318
• Gene Name: IL-6
• Condition: Leukocytospermia, oligoasthenozoospermia
• Association: Leukocytospermia is accompanied by an increase in IL-6 semen plasma level whereas IL-2 level remains statistically unchanged.
• Population size: 52
• Population details: 52 (16 fertile men, 16 with leukocytospermia, 20 with oligoasthenozoospermia)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: IL-2, IL-6
• Other associated phenotypes: Leukocytospermia, oligoasthenozoospermia

[The influence of asymptomatic leukocytospermia on interleukin IL-2 and IL-6 levels in male semen plasma]

Swatowski D, Jakiel G.

AIM: The study presents the results of the search for a correlation between leukocytospermia and the interleukin IL-2 and IL-6 levels in male semen plasma. MATERIAL AND METHODS: Interleukin levels were assessed by immunoenzymatic method (ELISA). Study covered 3 groups of males: I--fertile (No. = 16); II--with leukocytospermia (No = 16); III--with oligoasthenozoospermia (No = 20). RESULTS: The study revealed higher levels of IL-6 in a group of males with leukocytospermia (10.01 +/- 2.57 pg/ml) and with oligoasthenozoospermia (13.53 +/- 2.78 pg/ml) compared to a group of fertile males (7.68 +/- 1.4 pg/ml) (p < 0.01), however no statistically significant differences in IL-6 levels between group II and III have been observed. Higher level of IL-2 has been noted in III group (16.68 +/- 5.86 pg/ml) compared to I and II group (9.77 +/- 3.18 pg/ml and 6.05 +/- 2.16 pg/ml, respectively) (p < 0.01). No statistically significant difference in IL-2 semen plasma level between the fertile male group and the group with leukocytospermia has been revealed. CONCLUSION: Leukocytospermia is accompanied by an increase in IL-6 semen plasma level whereas IL-2 level remains statistically unchanged. FAU - Swatowski, Dariusz AU - Swatowski D AD - Kliniki Rozrodczości i Andrologii AM w Lublinie.