• PMID: 12508124
• Gene Name: EGFR
• Condition: cryptorchid boys
• Association: The EGF and EGFR expressions may correlate with the age and the position of testes; orchiopexy improves the EGF and EGFR expressions in cryptorchid boys.
• PMID: 12508124
• Gene Name: EGFR
• Condition: Cryptorchid
• Association: The EGF and EGFR expressions may correlate with the age and the position of testes; orchiopexy improves the EGF and EGFR expressions in cryptorchid boys.
• Sex: Male
• Infertility type: Male infertility
• Associated genes: EGF, EGFR
• Other associated phenotypes: Cryptorchid

Clinical significance of EGF and EGFR expression changes in cryptorchid boys

Yang GS, Lu RK, Chen ZD.

AIM: To explore the changes of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) expressions in cryptorchid children and their clinical significance. METHODS: The level of serum EGF was measured by radioimmunoassay (RIA) and the expression of EGFR by immunohistochemistry. RESULTS: (1) The level of serum EGF was significantly lower in cryptorchid children than in normal subjects at age group of 5-9 years (P<0.01) and 10-14 years (P<0.01), (2) The level of EGF was significantly lower in boys with impalpable testis than in those with extracanalicular and intracanalicular testes (P<0.01), (3) The serum EGF level increased significantly 6 months after orchiopexy (P<0.05), (4) The EGFR expression in testicular Leydig's cells was lower in 2 approximately 4 year-old boys than in those over 5 years (P<0.05) and (5) the EGFR expression was less positive in the impalpable group and the intracanalicular group than that of the extracanalicular group (P<0.01). CONCLUSION: The EGF and EGFR expressions may correlate with the age and the position of testes; orchiopexy improves the EGF and EGFR expressions in cryptorchid boys. FAU - Yang, Guo-Sheng AU - Yang GS AD - Department of Urology, First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China. ywy2008@163.com FAU - Lu, Ren-Kang AU - Lu RK