• PMID: 12491684
• Gene Name: DAZ1
• Condition: Infertility
• Association: The authors conclude that no deletions were observed in YRRM1, DAZ and DYS240 genes on Y chromosome. Chromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of transl
• Mutation: Balanced translocation t(1;12) (q24;q24)
• Population size: 2
• Population details: 2 infertile
• Sex: Male
• Infertility type: Male infertility
• Associated genes: YRRM1, DYS240

[Study on the relationship of balanced translocation t(1;12) with spermatogenesis]

Zhou ZM, Liu JY, Xu M, Sha JH, Lin M, Zhou YD, Wang LR, Li JM.

OBJECTIVES: To investigate the relationship between chromosome balanced translocation t(1;12) (q24;q24) and spermatogenesis in infertile twin brothers. METHODS: For twin brothers, karotype were determined. The levels of testosterone, FSH and LH were detected. YRRM1, DAZ and DYS240 were analyzed. In younger brother a biopsy was taken from testis. RESULTS: Chromosome analysis for both twin brothers revealed a karotype of 46, XY, t(1;12) (q24;q24). Sperm count was less than 1.0 x 10(6)/ml. There was no deletion for YRRM1, DAZ and DYS240 gene on Y chromosome. Photomicrograph of seminiferous tubules showed the arrest of spermatogenesis. CONCLUSIONS: Chromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of translocation may be related to spermatogenesis. FAU - Zhou, Zuo-Min AU - Zhou ZM AD - Department of Histology and Embryology, Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China. FAU - Liu, Jia-Yin AU - Liu JY FAU - Xu, Min AU - Xu M FAU - Sha, Jia-Hao AU - Sha JH FAU - Lin, Min AU - Lin M FAU - Zhou, Ya-Dong AU - Zhou YD FAU - Wang, Li-Rong AU - Wang LR