• PMID: 12085101
• Gene Name: DAZ1
• Condition: Infertility
• Association: Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia
• Mutation: Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255
• Population size: 29
• Population details: 29 idiopathic azoospermia
• Sex: Male
• Infertility type: Male infertility

Microdeletions in the Y chromosome of patients with idiopathic azoospermia

Shimizu A, Ichikawa T, Suzuki N, Yamazaki T, Imamoto T, Kojima S, Naya Y, Komiya A, Suzuki H, Nagao K, Miura K, Ito H.

AIM: To evaluate the occurrence and prevalence of microdeletions in the gamma chromosome of patients with azoospermia. METHODS: DNA from 29 men with idiopathic azoospermia was screened by polymerase chain reaction (PCR) analysis with a set of gamma chromosome specific sequence-tagged sites (STSs) to determine microdeletions in the gamma chromosome. RESULTS: Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men. CONCLUSION: We conclude that PCR analysis is useful for the diagnosis of microdeletions in the Y chromosome, which is important when deciding the suitability of a patient for assisted reproductive technology such as testicular sperm extracion-intracytoplasmic sperm injection (TESE-ICSI). FAU - Shimizu, Akiyuki AU - Shimizu A AD - Department of Urology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. FAU - Ichikawa, Tomohiko AU - Ichikawa T FAU - Suzuki, Noriyuki AU - Suzuki N FAU - Yamazaki, Takako AU - Yamazaki T FAU - Imamoto, Takashi AU - Imamoto T FAU - Kojima, Satoko AU - Kojima S FAU - Naya, Yukio AU - Naya Y FAU - Komiya, Akira AU - Komiya A FAU - Suzuki, Hiroyoshi AU - Suzuki H FAU - Nagao, Koichi AU - Nagao K FAU - Miura, Kazukiyo AU - Miura K