• PMID: 11966576
• Gene Name: EGFR
• Condition: Nonobstructive�azoospermia
• Association: The mean�epidermal growth factor receptor�expression was higher in immotile than motile�sperm�obtained tissue. However, further studies are required to investigate the relationship between other growth factors and sperm fertilization capacity.
• PMID: 11966576
• Gene Name: EGFR
• Condition: sperm�fertilization capacity
• Association: There was no statistically significant relationship between the extracellular matrix protein and�epidermal growth factor�receptor expression patterns and�sperm�motility, fertilization and pregnancy rates intesticular�sperm�extraction and intracytoplasmic
• Population size: 88
• Population details: 88 patients with nonobstructive�azoospermia
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: sperm�fertilization capacity

The role of expression of extracellular matrix proteins and epidermal growth factor receptor activity on fertilization capacity of testicular harvested spermatozoa

Erdo?ru T, G�lkesen KH, Bah�eci M, Karpuzo?lu G, Baykara M.

It has been suggested that multiple growth factors are crucial for spermatogenesis. We analyzed whether alterations on epidermal growth factor receptor activity and different expression pattern of extracellular matrix proteins had an impact on the fertilization capacity of spermatozoa and pregnancy rate after testicular sperm extraction and intracytoplasmic injection. Extracellular matrix proteins and epidermal growth factor receptor were immunohistochemically evaluated in testis of 88 patients with nonobstructive azoospermia. Testicular sperm extraction and intracytoplasmic injection procedure was also performed in 32 of the patients for whom mature sperm could be harvested from the testicular tissue. While collagen Type-IV and laminin activity percentages were 33.1% and 86.4% in motile sperm harvested testicular tissue, these activities were 23.3% and 89.3% in immotile sperm harvested testicular tissue, respectively. In addition, the mean epidermal growth factor receptor expression was higher in immotile than motile sperm obtained tissue (56.4% vs. 51.1%, P=0.4928). There was no statistically significant relationship between the extracellular matrix protein and epidermal growth factor receptor expression patterns and sperm motility, fertilization and pregnancy rates in testicular sperm extraction and intracytoplasmic injection. However, further studies are required to investigate the relationship between other growth factors and sperm fertilization capacity. FAU - Erdoĝru, T AU - Erdoĝru T AD - Department of Urology, Akdeniz University Faculty of Medicine, Antalya, Turkey. terdogru@hipokrat.med.akdeniz.edu.tr FAU - Gülkesen, K H AU - Gülkesen KH FAU - Bahçeci, M AU - Bahçeci M FAU - Karpuzoĝlu, G AU - Karpuzoĝlu G