• PMID: 11940664
• Gene Name: SH2B1
• Condition: Impaired fertility in male and female
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Impaired fertility in male and female

SH2-B is required for both male and female reproduction

Ohtsuka S, Takaki S, Iseki M, Miyoshi K, Nakagata N, Kataoka Y, Yoshida N, Takatsu K, Yoshimura A.

Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I receptors, although the role of SH2-B in these signals has not been clarified. To investigate the role of SH2-B, we generated mice with a targeted disruption of the SH2-B gene. Both male and female SH2-B(-/-) mice showed slight retardation in growth and impaired fertility. Female knockout mice possess small, anovulatory ovaries with reduced numbers of follicles and male SH2-B(-/-) mice have small testes with a reduced number of sperm. SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice. FAU - Ohtsuka, Satoshi AU - Ohtsuka S AD - Division of Molecular Genetics, Institute of Life Science, Kurume University, Kurume 839-0861, USA. FAU - Takaki, Satoshi AU - Takaki S FAU - Iseki, Masanori AU - Iseki M FAU - Miyoshi, Kanta AU - Miyoshi K FAU - Nakagata, Naomi AU - Nakagata N FAU - Kataoka, Yuki AU - Kataoka Y FAU - Yoshida, Nobuaki AU - Yoshida N FAU - Takatsu, Kiyoshi AU - Takatsu K