• PMID: 11881732
• Gene Name: TP53
• Condition: Azoospermia, Leydig cell tumors
• Association: The study recommends the evaluation of infertile men for Leydig cell tumors, and we believe that a panel of antibodies, including Ki-67, p53 and bcl-2, used for immunohistochemical analysis could be of diagnostic value in the identification of malignant a
• Population size: 4
• Population details: 4 (3 azoospermia, 1 leydig cell tumor )
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Azoospermia, leydig cell tumors

Leydig cell tumor of the testis: comparison of histopathological and immunohistochemical features of three azoospermic cases and one malignant case

Hekimgil M, Altay B, Yakut BD, Soydan S, Ozyurt C, Killi R.

Leydig cell tumors of the testis are rare, mostly presenting as a testicular mass or as endocrinological symptoms. Here, three patients who were admitted for investigation of primary infertility and one patient presenting with a testicular mass are reported. The histological features were reviewed and an immunohistochemical study was done using a panel of antibodies against cytokeratin, vimentin, inhibin A, S-100, Ki-67, follicle-stimulating hormone, luteinizing hormone, prolactin, p53, bcl-2, and c-erbB2. The latter case (lost during follow up of metastatic disease) demonstrated massive tumor necrosis, extension through the tunica albuginea, and a high mitotic activity and MIB-1 score. Only this malignant case was bcl-2 positive. Of the two oncogenic markers studied, none of the cases were positive for c-erb2, while p53 was positive in more than 50% of cells in the malignant case and in one case of infertility with a large tumor, hemorrhage, focal necrosis and atypical cytological features. We recommend the evaluation of infertile men for Leydig cell tumors, and we believe that a panel of antibodies, including Ki-67, p53 and bcl-2, used for immunohistochemical analysis could be of diagnostic value in the identification of malignant and borderline cases of Leydig cell tumor. FAU - Hekimgil, M AU - Hekimgil M AD - Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey. hekimgil@alpha.med.ege.edu.tr FAU - Altay, B AU - Altay B FAU - Yakut, B D AU - Yakut BD FAU - Soydan, S AU - Soydan S FAU - Ozyurt, C AU - Ozyurt C