• PMID: 11591424
• Gene Name: AR
• Condition: Cryptorchidism
• Association: AR gene alterations appear to be an unlikely cause of isolated cryptorchidism.
• Population size: 68
• Population details: 68 (48 patients with cryptorchidism, 20 normal phenotypic men as controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Cryptorchidism

Screening for mutations of the androgen receptor gene in patients with isolated cryptorchidism

Suzuki Y, Sasagawa I, Ashida J, Nakada T, Muroya K, Ogata T.

OBJECTIVE: To evaluate the occurrence of mutations of androgen receptor (AR) gene in patients with isolated cryptorchidism. DESIGN: Controlled clinical study. SETTING: Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan. PATIENT(S): Patients with isolated cryptorchidism (n = 48) and a control group of men with normal phenotype (n = 20). INTERVENTION(S): Blood (lymphocyte DNA). MAIN OUTCOME MEASURE(S): Screening of the AR gene in exons 1-8 using single-strand conformational polymorphism analysis. RESULT(S): No abnormal band patterns were detected in patients with cryptorchidism or in control subjects within the eight exons of the AR gene. CONCLUSION(S): AR gene alterations appear to be an unlikely cause of isolated cryptorchidism. FAU - Suzuki, Y AU - Suzuki Y AD - Department of Urology, Yamagata University School of Medicine, Yamagata, Japan. FAU - Sasagawa, I AU - Sasagawa I FAU - Ashida, J AU - Ashida J FAU - Nakada, T AU - Nakada T FAU - Muroya, K AU - Muroya K