• PMID: 11525089
• Gene Name: DAZ1
• Condition: Infertility
• Association: The study concludes that the exact biological role and function of the DAZ protein has yet to be resolved
• Mutation: DAZ- gene deletion
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Oligozoospermia, Azoospermia

[From gene to disease; deletion of the DAZ-gene from the Y-chromosome in oligo- or azoospermia ]

Tuerlings JH, Hoefsloot LH, Kremer JA.

DAZ gene deletions at the azoospermia factor (AZF) locus on the Y chromosome, have been implicated as one of the major causes of idiopathic male subfertility. Deletions of the entire DAZ gene have been reported in azoospermia as well as in oligozoospermia. The DAZ gene encodes a RNA binding protein which is expressed exclusively in germ cells. The exact biological role and function of the DAZ protein has yet to be resolved. FAU - Tuerlings, J H AU - Tuerlings JH AD - Afd. Antropogenetica, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen. j.tuerlings@antrg.azn.nl FAU - Hoefsloot, L H AU - Hoefsloot LH