• PMID: 11267678
• Gene Name: ZNF463
• Condition: Azoospermia
• Association: As from Northern blot analysis ZNF463 is only expressed in testis, RT-PCR indicates that ZNF463 is expressed more highly in normal fertile adults than in fetus and azoospermic patients suggesting that it may play a role in human spermatogenesis.
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Azoospermia

Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463

Wu H, Zhang S, Qiu W, Zhang G, Xia Q, Xiao C, Huang X, Huang M, Agen P, Fan T, Yang J, Milunsky A.

A novel human KRAB (Krüppel associated box) type zinc finger protein encoding gene, ZNF463, was obtained by mRNA differential display and RACE. It consists of 1904 nucleotides and encodes a protein of 463 amino acids with an amino-terminal KRAB domain and 12 carboxy-terminal C2H2 zinc finger units. The gene is mapped to chromosome 19q13.3 approximately 4 by FISH. As from Northern blot analysis ZNF463 is only expressed in testis, RT-PCR indicates that ZNF463 is expressed more highly in normal fertile adults than in fetus and azoospermic patients suggesting that it may play a role in human spermatogenesis. FAU - Wu, H AU - Wu H AD - Department of Medical Genetics, First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, PR China. FAU - Zhang, S AU - Zhang S FAU - Qiu, W AU - Qiu W FAU - Zhang, G AU - Zhang G FAU - Xia, Q AU - Xia Q FAU - Xiao, C AU - Xiao C FAU - Huang, X AU - Huang X FAU - Huang, M AU - Huang M FAU - Agen, P AU - Agen P FAU - Fan, T AU - Fan T FAU - Yang, J AU - Yang J