• PMID: 11232795
• Gene Name: IL-2R
• Condition: Male infertility
• Association: The sIL-2R level in serum was significantly higher and the Na+K+-exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls.
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

Changes in soluble interleukin-2 receptor level in serum and Na+-K+-exchanging ATPase activity in semen of infertile men caused by antisperm antibody

Ni J, Li QL, Zhang W, Xie JS, Bian SL.

AIM: To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb). METHODS: The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na+-K+-exchanging ATPase activity in semen by phosphorus (Pi) assay. RESULTS: The sIL-2R level in serum was significantly higher and the Na+K+-exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls. CONCLUSION: The AsAb titer varies with the sIL-2R level in serum. A decrease in Na+-K+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb. FAU - Ni, J AU - Ni J AD - Department of Physiology, Harbin Medical University, China. liql@ems.hrbmu.edu.cn FAU - Li, Q L AU - Li QL FAU - Zhang, W AU - Zhang W FAU - Xie, J S AU - Xie JS