• PMID: 10462493
• Gene Name: HDGFL1
• Condition: Associated with spermatogenesis
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Associated with spermatogenesis

Hepatoma-derived growth factor-related protein (HRP)-1 gene in spermatogenesis in mice

Kuroda T, Tanaka H, Nakamura H, Nishimune Y, Kishimoto T.

Hepatoma-derived growth factor (HDGF)-related protein (HRP)-1, a member of the HDGF gene family, showed testis-specific expression in mice. HRP-1 expression in spermatogenesis was analyzed in the testis of normal and azoospermic mice by Northern blot and immunohistochemistry. HRP-1 gene message was not expressed in the ovary and its product was detected only in the nuclei of germ cells, not in somatic cells. The HRP-1 gene is expressed through pachytene spermatocyte to round spermatid. HRP-1 gene expression was not detected in the testis of cryptorchid mice or in some strains of mutant mice. These findings suggest that the testis-specific HRP-1 gene may play an important role in the phase around meiotic cell division. CI - Copyright 1999 Academic Press. FAU - Kuroda, T AU - Kuroda T AD - Department of Molecular Medicine, Osaka University Medical School, Osaka, Japan. toshik@imed3.med.osaka-u.ac.jp FAU - Tanaka, H AU - Tanaka H FAU - Nakamura, H AU - Nakamura H FAU - Nishimune, Y AU - Nishimune Y