• Gene id: 9982

Gene Summary

• Gene Symbol: FGFBP1   Gene   UCSC   Ensembl
• Aliases: FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17
• Gene name: fibroblast growth factor binding protein 1
• Alternate names: fibroblast growth factor-binding protein 1, 17 kDa HBGF-binding protein, 17 kDa heparin-binding growth factor-binding protein, FGF-binding protein 1, heparin-binding growth factor binding protein,
• Gene location: 4p15.32 (15938739: 15935576)     Exons: 3     NC_000004.12
• Gene summary(Entrez): This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on targ
• OMIM: 617582

Protein Summary

• Protein general information: Q14512  
  • Name: Fibroblast growth factor binding protein 1 (FGF BP) (FGF BP1) (FGF binding protein 1) (FGFBP 1) (17 kDa heparin binding growth factor binding protein) (17 kDa HBGF binding protein) (HBp17)
  • Length: 234  
  • Mass: 26264
  • Tissue specificity: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasiv
• Sequence:

  MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQ
  EEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKL
  VSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFF
  LSIVQDTSC

• Structural information:
  • Interpro: IPR010510  
  • STRING: ENSP00000371770
• Other Databases: GeneCards:  FGFBP1  Malacards:  FGFBP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007267	cell-cell signaling	IBA	biological process
GO:0019838	growth factor binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0019838	growth factor binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0008201	heparin binding	TAS	molecular function
GO:0005615	extracellular space	TAS	cellular component
GO:0007165	signal transduction	NAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0008285	negative regulation of cell population proliferation	TAS	biological process
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0008284	positive regulation of cell population proliferation	IEA	biological process
GO:0017134	fibroblast growth factor binding	IEA	molecular function
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	IEA	biological process
GO:0009986	cell surface	IEA	cellular component
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IDA	biological process
GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R