• Gene id: 9898

Gene Summary

• Gene Symbol: UBAP2L   Gene   UCSC   Ensembl
• Aliases: NICE-4, NICE4
• Gene name: ubiquitin associated protein 2 like
• Alternate names: ubiquitin-associated protein 2-like, protein NICE-4,
• Gene location: 1q21.3 (154220171: 154271509)     Exons: 34     NC_000001.11
• OMIM: 602095

Protein Summary

• Protein general information: Q14157  
  • Name: Ubiquitin associated protein 2 like (Protein NICE 4)
  • Length: 1087  
  • Mass: 114535
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MMTSVGTNRARGNWEQPQNQNQTQHKQRPQATAEQIRLAQMISDHNDADFEEKVKQLIDITGKNQDECVIALHDC
  NGDVNRAINVLLEGNPDTHSWEMVGKKKGVSGQKDGGQTESNEEGKENRDRDRDYSRRRGGPPRRGRGASRGREF
  RGQENGLDGTKSGGPSGRGTERGRRGRGRGRGGSGRRGGRFSAQGMGTFNPADYAEPANTDDNYGNSSGNTWNNT
  GHFEPDDGTSAWRTATEEWGTEDWNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSTMENDSS
  NLDPSQAPSLAQPLVFSNSKQTAISQPASGNTFSHHSMVSMLGKGFGDVGEAKGGSTTGSQFLEQFKTAQALAQL
  AAQHSQSGSTTTSSWDMGSTTQSPSLVQYDLKNPSDSAVHSPFTKRQAFTPSSTMMEVFLQEKSPAVATSTAAPP
  PPSSPLPSKSTSAPQMSPGSSDNQSSSPQPAQQKLKQQKKKASLTSKIPALAVEMPGSADISGLNLQFGALQFGS
  EPVLSDYESTPTTSASSSQAPSSLYTSTASESSSTISSNQSQESGYQSGPIQSTTYTSQNNAQGPLYEQRSTQTR
  RYPSSISSSPQKDLTQAKNGFSSVQATQLQTTQSVEGATGSAVKSDSPSTSSIPPLNETVSAASLLTTTNQHSSS
  LGGLSHSEEIPNTTTTQHSSTLSTQQNTLSSSTSSGRTSTSTLLHTSVESEANLHSSSSTFSTTSSTVSAPPPVV
  SVSSSLNSGSSLGLSLGSNSTVTASTRSSVATTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQM
  LQTRFPLDYYSIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNP
  ALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNASATPFQQPSGYGSHGYNTGVSVTSSN
  TGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLPSALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQILHHH
  LQQDGQTGSGQRSQTSSIPQKPQTNKSAYNSYSWGAN

• Structural information:
  • Protein Domains: (49..8-)
    (/note="UBA-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00212"-)
  • Interpro: IPR015940  IPR009060  IPR022166  
  • Prosite: PS50030
  • STRING: ENSP00000389445
• Other Databases: GeneCards:  UBAP2L  Malacards:  UBAP2L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0061484	hematopoietic stem cell homeostasis	IBA	biological process
GO:0034063	stress granule assembly	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0031519	PcG protein complex	IDA	cellular component
GO:0061484	hematopoietic stem cell homeostasis	IGI	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0061484	hematopoietic stem cell homeostasis	IEA	biological process
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	IDA	colocalizes with
GO:0010494	cytoplasmic stress granule	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0007339	binding of sperm to zona pellucida	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R