• Gene id: 9836

Gene Summary

• Gene Symbol: LCMT2   Gene   UCSC   Ensembl
• Aliases: PPM2, TYW4
• Gene name: leucine carboxyl methyltransferase 2
• Alternate names: tRNA wybutosine-synthesizing protein 4, p21WAF1/CIP1 promoter-interacting protein, tRNA yW-synthesizing protein 4, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-,
• Gene location: 15q15.3 (43330572: 43323648)     Exons: 1     NC_000015.10
• Gene summary(Entrez): The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hyper
• OMIM: 176258

Protein Summary

• Protein general information: O60294  
  • Name: tRNA wybutosine synthesizing protein 4 (tRNA yW synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7 (3 amino 3 (methoxycarbonyl)propyl)wyosine(37) N) methoxycarbonyltransferase) (tRNA(Phe) (7 (3 amino
  • Length: 686  
  • Mass: 75602
• Sequence:

  MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRARAVRHCVRAFLEQIG
  APQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPELCALTGPFERGEPASALCF
  ESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQD
  AFGQFMLQHFRQLNSPLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWH
  LKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGHASVFLSPDVILSAGG
  FGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLH
  FFKSEDNNTEDLKVTITKAGRKDDSTLCCWRHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIP
  VEGEVPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLL
  VGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGGGNCFSFGTYFNPHTV
  TLDLSSLSAGQ

• Structural information:
  • Interpro: IPR015915  IPR007213  IPR029063  
  • STRING: ENSP00000307214
• Other Databases: GeneCards:  LCMT2  Malacards:  LCMT2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030488	tRNA methylation	IBA	biological process
GO:0031591	wybutosine biosynthetic process	IBA	biological process
GO:0008175	tRNA methyltransferase activity	IBA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008033	tRNA processing	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0006400	tRNA modification	TAS	biological process
GO:0008175	tRNA methyltransferase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881