• Gene id: 978

Gene Summary

• Gene Symbol: CDA   Gene   UCSC   Ensembl
• Aliases: CDD
• Gene name: cytidine deaminase
• Alternate names: cytidine deaminase, cytidine aminohydrolase, cytosine nucleoside deaminase, small cytidine deaminase,
• Gene location: 1p36.12 (20589096: 20618902)     Exons: 4     NC_000001.11
• Gene summary(Entrez): This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several dea
• OMIM: 123920

Protein Summary

• Protein general information: P32320  
  • Name: Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)
  • Length: 146  
  • Mass: 16185
  • Tissue specificity: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
• Sequence:

  MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAV
  SEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ

• Structural information:
  • Protein Domains: (13..14-)
    (/note="CMP/dCMP-type-deaminase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01083"-)
  • Interpro: IPR016192  IPR002125  IPR006262  IPR016193  
  • Prosite: PS00903 PS51747
  • PDB: 1MQ0
  • PDBsum: 1MQ0
  • STRING: ENSP00000364212
• Other Databases: GeneCards:  CDA  Malacards:  CDA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009972	cytidine deamination	IBA	biological process
GO:0004126	cytidine deaminase activity	IBA	molecular function
GO:0008270	zinc ion binding	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0008270	zinc ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0004126	cytidine deaminase activity	IEA	molecular function
GO:0009972	cytidine deamination	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004126	cytidine deaminase activity	IEA	molecular function
GO:0043097	pyrimidine nucleoside salvage	TAS	biological process
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904724	tertiary granule lumen	TAS	cellular component
GO:1904813	ficolin-1-rich granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0034774	secretory granule lumen	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0030308	negative regulation of cell growth	IDA	biological process
GO:0008270	zinc ion binding	IDA	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0004126	cytidine deaminase activity	IDA	molecular function
GO:0004126	cytidine deaminase activity	IDA	molecular function
GO:0045980	negative regulation of nucleotide metabolic process	IDA	biological process
GO:0001882	nucleoside binding	IDA	molecular function
GO:0009972	cytidine deamination	IDA	biological process
GO:0008655	pyrimidine-containing compound salvage	NAS	biological process
GO:0005829	cytosol	NAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0019858	cytosine metabolic process	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00983	Drug metabolism - other enzymes
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
lung non-small cell carcinoma	PMID:18347182
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)