• Gene id: 9748

Gene Summary

• Gene Symbol: SLK   Gene   UCSC   Ensembl
• Aliases: LOSK, STK2, bA16H23.1, se20-9
• Gene name: STE20 like kinase
• Alternate names: STE20-like serine/threonine-protein kinase, CTCL tumor antigen se20-9, Long Ste20-like Kinase, SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase, SNF1 sucrose nonfermenting like kinase, STE20-related kinase, STE20-,
• Gene location: 10q24.33-q25.1 (103967099: 104029232)     Exons: 19     NC_000010.11
• OMIM: 616563

Protein Summary

• Protein general information: Q9H2G2  
  • Name: STE20 like serine/threonine protein kinase (STE20 like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20 9) (STE20 related serine/threonine protein kinase) (STE20 related kinase) (Serine/threonine protein kinase 2)
  • Length: 1235  
  • Mass: 142695
  • Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. {ECO
• Sequence:

  MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELED
  YMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNK
  IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITL
  IEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI
  RELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDK
  LNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEG
  KENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKE
  DTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEV
  PIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKV
  TTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDS
  GTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRF
  LRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRL
  RDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSL
  KKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQ
  RYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQ
  KHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQ
  EVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS

• Structural information:
  • Protein Domains: (34..29-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159-)
    (875..91-)
    (/note="UVR-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00217"-)
  • Interpro: IPR011009  IPR022165  IPR000719  IPR017441  IPR008271   IPR001943  
  • Prosite: PS00107 PS50011 PS00108 PS50151
  • PDB: 2J51 2JFL 2JFM 2UV2 4USF 6HVD
  • PDBsum: 2J51 2JFL 2JFM 2UV2 4USF 6HVD
  • STRING: ENSP00000358770
• Other Databases: GeneCards:  SLK  Malacards:  SLK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031098	stress-activated protein kinase signaling cascade	IBA	biological process
GO:0023014	signal transduction by protein phosphorylation	IBA	biological process
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0032147	activation of protein kinase activity	IBA	biological process
GO:0007346	regulation of mitotic cell cycle	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0051893	regulation of focal adhesion assembly	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0042981	regulation of apoptotic process	IDA	biological process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0046777	protein autophosphorylation	IDA	biological process
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0031122	cytoplasmic microtubule organization	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0030334	regulation of cell migration	IMP	biological process
GO:0030334	regulation of cell migration	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0031252	cell leading edge	ISS	cellular component
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0006915	apoptotic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0030334	regulation of cell migration	IEA	biological process
GO:0031252	cell leading edge	IEA	cellular component
GO:0045296	cadherin binding	HDA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04114	Oocyte meiosis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881