• Gene id: 9728

Gene Summary

• Gene Symbol: SECISBP2L   Gene   UCSC   Ensembl
• Aliases: SBP2L, SLAN
• Gene name: SECIS binding protein 2 like
• Alternate names: selenocysteine insertion sequence-binding protein 2-like,
• Gene location: 15q21.1 (49046445: 48988637)     Exons: 18     NC_000015.10
• OMIM: 0

Protein Summary

• Protein general information: Q93073  
  • Name: Selenocysteine insertion sequence binding protein 2 like (SECIS binding protein 2 like)
  • Length: 1101  
  • Mass: 121776
• Sequence:

  MDRAPTEQNVKLSAEVEPFIPQKKSPDTFMIPMALPNDNGSVSGVEPTPIPSYLITCYPFVQENQSNRQFPLYNN
  DIRWQQPNPNPTGPYFAYPIISAQPPVSTEYTYYQLMPAPCAQVMGFYHPFPTPYSNTFQAANTVNAITTECTER
  PSQLGQVFPLSSHRSRNSNRGSVVPKQQLLQQHIKSKRPLVKNVATQKETNAAGPDSRSKIVLLVDASQQTDFPS
  DIANKSLSETTATMLWKSKGRRRRASHPTAESSSEQGASEADIDSDSGYCSPKHSNNQPAAGALRNPDSGTMNHV
  ESSMCAGGVNWSNVTCQATQKKPWMEKNQTFSRGGRQTEQRNNSQVGFRCRGHSTSSERRQNLQKRPDNKHLSSS
  QSHRSDPNSESLYFEDEDGFQELNENGNAKDENIQQKLSSKVLDDLPENSPINIVQTPIPITTSVPKRAKSQKKK
  ALAAALATAQEYSEISMEQKKLQEALSKAAGKKNKTPVQLDLGDMLAALEKQQQAMKARQITNTRPLSYTVVTAA
  SFHTKDSTNRKPLTKSQPCLTSFNSVDIASSKAKKGKEKEIAKLKRPTALKKVILKEREEKKGRLTVDHNLLGSE
  EPTEMHLDFIDDLPQEIVSQEDTGLSMPSDTSLSPASQNSPYCMTPVSQGSPASSGIGSPMASSTITKIHSKRFR
  EYCNQVLCKEIDECVTLLLQELVSFQERIYQKDPVRAKARRRLVMGLREVTKHMKLNKIKCVIISPNCEKIQSKG
  GLDEALYNVIAMAREQEIPFVFALGRKALGRCVNKLVPVSVVGIFNYFGAESLFNKLVELTEEARKAYKDMVAAM
  EQEQAEEALKNVKKVPHHMGHSRNPSAASAISFCSVISEPISEVNEKEYETNWRNMVETSDGLEASENEKEVSCK
  HSTSEKPSKLPFDTPPIGKQPSLVATGSTTSATSAGKSTASDKEEVKPDDLEWASQQSTETGSLDGSCRDLLNSS
  ITSTTSTLVPGMLEEEEDEDEEEEEDYTHEPISVEVQLNSRIESWVSETQRTMETLQLGKTLNGSEEDNVEQSGE
  EEAEAPEVLEPGMDSEAWTADQQASPGQQKSSNCSSLNKEHSDSNYTTQTT

• Structural information:
  • Interpro: IPR029064  IPR004038  IPR040051  
  • STRING: ENSP00000453854
• Other Databases: GeneCards:  SECISBP2L  Malacards:  SECISBP2L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001514	selenocysteine incorporation	IBA	biological process
GO:1990904	ribonucleoprotein complex	IBA	cellular component
GO:0003730	mRNA 3'-UTR binding	IBA	molecular function
GO:0035368	selenocysteine insertion sequence binding	IBA	molecular function
GO:0043021	ribonucleoprotein complex binding	IBA	molecular function
GO:0035368	selenocysteine insertion sequence binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq