• Gene id: 969

Gene Summary

• Gene Symbol: CD69   Gene   UCSC   Ensembl
• Aliases: AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
• Gene name: CD69 molecule
• Alternate names: early activation antigen CD69, C-type lectin domain family 2, member C, CD69 antigen (p60, early T-cell activation antigen), activation inducer molecule (AIM/CD69), early T-cell activation antigen p60, early lymphocyte activation antigen, leukocyte surfac,
• Gene location: 12p13.31 (9760900: 9752485)     Exons: 5     NC_000012.12
• Gene summary(Entrez): This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may ac
• OMIM: 107273

Protein Summary

• Protein general information: Q07108  
  • Name: Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL AC/P26) (C type lectin domain family 2 member C) (EA1) (Early T cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu 23) (MLR 3) (CD antigen CD69)
  • Length: 199  
  • Mass: 22,559
• Sequence:

  MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFS
  MPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPG
  HPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK

• Structural information:
  • Protein Domains: C-type (92-195)
  • Interpro: IPR001304  IPR016186  IPR016187  IPR033992  
  • Prosite: PS50041
  • CDD: cd03593
  • PDB: 1E87 1E8I 1FM5 3CCK 3HUP
  • PDBsum: 1E87 1E8I 1FM5 3CCK 3HUP
  • DIP: 60426
  • STRING: ENSP00000228434
• Other Databases: GeneCards:  CD69  Malacards:  CD69

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004888	transmembrane signaling receptor activity	TAS	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0035690	cellular response to drug	IEA	biological process
GO:0004888	transmembrane signaling receptor activity	TAS	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0035690	cellular response to drug	IEA	biological process
GO:0004888	transmembrane signaling receptor activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component

Diseases

Associated diseases	References
Addison's disease	GAD: 18593762
Arthritis	GAD: 18627570
Diabetes	GAD: 19430480
Endometriosis	INFBASE: 16533339
Female infertility	INFBASE: 15259373
Recurrent pregnancy loss (RPL)	INFBASE: 11331628
Unexplained infertility	MIK: 24597237
Male factor infertility	MIK: 24597237
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospadias	MIK: 24778562
Unexplained infertility	MIK: 24597237

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24597237	Unexplained infertility			20 normozoospermic infertile men	Male infertility	CD52 CD69 CD98 fMLP HI307 and 80280
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
24778562	Hypospadias			13 (5 controls, 8 cases)	Male infertility	Microarray