• Gene id: 9665

Gene Summary

• Gene Symbol: MARF1   Gene   UCSC   Ensembl
• Aliases: KIAA0430, LKAP, LMKB, PPP1R34
• Gene name: meiosis regulator and mRNA stability factor 1
• Alternate names: meiosis regulator and mRNA stability factor 1, limkain-b1, meiosis arrest female 1, meiosis arrest female protein 1, protein phosphatase 1, regulatory subunit 34,
• Gene location: 16p13.11 (15643165: 15594386)     Exons: 28     NC_000016.10
• Gene summary(Entrez): This gene encodes a putative peroxisomal protein that appears to be conserved across Euteleostomi. In humans, it may be autoantigenic. [provided by RefSeq, Jul 2010]
• OMIM: 616967

Protein Summary

• Protein general information: Q9Y4F3  
  • Name: Meiosis regulator and mRNA stability factor 1 (Limkain b1) (Meiosis arrest female protein 1)
  • Length: 1742  
  • Mass: 192859
• Sequence:

  MMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVELKDVPSPLHAGSKLF
  PAVPLPDIRSLQQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGGGGSGGTSSLIHPGALLDSQSTRTITCQVGS
  GFAFQSASSLQNASARNNLAGIASDFPSMCLESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFP
  CSDFTSGAPGHLEEHISQSELTPHLCTNSLHLNVVPPVCLKGSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQP
  APLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVFWDIENCSVPSGRSATAVVQ
  RIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATVVLVS
  TDVNFALELSDLRHRHGFHIILVHKNQASEALLHHANELIRFEEFISDLPPRLPLKMPQCHTLLYVYNLPANKDG
  KSVSNRLRRLSDNCGGKVLSITGCSAILRFINQDSAERAQKRMENEDVFGNRIIVSFTPKNRELCETKSSNAIAD
  KVKSPKKLKNPKLCLIKDASEQSSSAKATPGKGSQANSGSATKNTNVKSLQELCRMESKTGHRNSEHQQGHLRLV
  VPTHGNSSAAVSTPKNSGVAEPVYKTSQKKENLSARSVTSSPVEKKDKEETVFQVSYPSAFSKLVASRQVSPLLA
  SQSWSSRSMSPNLLNRASPLAFNIANSSSEADCPDPFANGADVQVSNIDYRLSRKELQQLLQEAFARHGKVKSVE
  LSPHTDYQLKAVVQMENLQDAIGAVNSLHRYKIGSKKILVSLATGAASKSLSLLSAETMSVLQDAPACCLPLFKF
  TDIYEKKFGHKLNVSDLYKLTDTVAIREQGNGRLVCLLPSSQARQSPLGSSQSHDGSSTNCSPIIFEELEYHEPV
  CRQHCSNKDFSEHEFDPDSYKIPFVILSLKTFAPQVHSLLQTHEGTVPLLSFPDCYIAEFGDLEVVQENQGGVPL
  EHFITCVPGVNIATAQNGIKVVKWIHNKPPPPNTDPWLLRSKSPVGNPQLIQFSREVIDLLKSQPSCVIPISHFI
  PSYHHHFAKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFTQDLLKLLKSQASKQVIVREF
  SQAYHWCFSKDWDVTEYGVCELIDIVSEIPDTTICLSQQDNEMVICIPKRERTQDEIERTKQFSKDVVDLLRHQP
  HFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLLELFEAIPDTLQVLECGEEKILTLTEVERFKALAAQFVKLLRSQ
  KDNCLMMTDLLTEYAKTFGYTFRLQDYDVSSISALTQKLCHVVKVADIESGRQIQLINRKSLRSLTAQLLVLLMS
  WEGTTHLSVEELKRHYESTHNTPLNPCEYGFMTLTELLKSLPYLVEVFTNDKMEECVKLTSLYLFAKNVRSLLHT
  YHYQQIFLHEFSMAYTKYVGETLQPKTYGHSSVEELLGAIPQVVWIKGHGHKRIVVLKNDMKSRLSSLSLSPANH
  ENQPSEGERILEVPESHTASELKLGADGSGPSHTEQELLRLTDDSPVDLLCAPVPSCLPSPQLRPDPVILQSADL
  IQFEERPQEPSEIMILNQEEKMEIPIPGKSKTLTSDSSSSCISAAVPVPPCPSSETSESLLSKDPVESPAKKQPK
  NRVKLAANFSLAPITKL

• Structural information:
  • Protein Domains: (353..49-)
    (/note="NYN-)
    (791..87-)
    (/note="RRM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176-)
    (875..94-)
    1 (/note="HTH-OST-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00975-)
    (1003..107-)
    2 (/note="HTH-OST-type)
    (/evi-)
  • Interpro: IPR041966  IPR024768  IPR024582  IPR034189  IPR034191   IPR012677  IPR021139  IPR025605  IPR035979  IPR000504  
  • Prosite: PS51644 PS50102
  • CDD: cd12255 cd12256
  • PDB: 2DGX 2DIU 6FDL
  • PDBsum: 2DGX 2DIU 6FDL
  • STRING: ENSP00000379654
• Other Databases: GeneCards:  MARF1  Malacards:  MARF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1905762	CCR4-NOT complex binding	IBA	molecular function
GO:0016441	posttranscriptional gene silencing	IBA	biological process
GO:1903231	mRNA binding involved in posttranscriptional gene silencing	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0010923	negative regulation of phosphatase activity	IDA	biological process
GO:0048477	oogenesis	ISS	biological process
GO:0007143	female meiotic nuclear division	ISS	biological process
GO:0010468	regulation of gene expression	ISS	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005777	peroxisome	IEA	cellular component
GO:0010468	regulation of gene expression	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0048477	oogenesis	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0005777	peroxisome	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010468	regulation of gene expression	IEA	biological process
GO:0006302	double-strand break repair	IEA	biological process
GO:0048477	oogenesis	IEA	biological process
GO:0007143	female meiotic nuclear division	IEA	biological process
GO:0005777	peroxisome	IEA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0005777	peroxisome	IDA	cellular component
GO:0003674	molecular_function	ND	molecular function
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881