• Gene id: 9644

Gene Summary

• Gene Symbol: SH3PXD2A   Gene   UCSC   Ensembl
• Aliases: FISH, SH3MD1, TKS5
• Gene name: SH3 and PX domains 2A
• Alternate names: SH3 and PX domain-containing protein 2A, SH3 multiple domains 1, adapter protein TKS5, adaptor protein TKS5, five SH3 domain-containing protein, tyrosine kinase substrate with five SH3 domains,
• Gene location: 10q24.33 (103855405: 103594026)     Exons: 16     NC_000010.11
• OMIM: 615114

Protein Summary

• Protein general information: Q5TCZ1  
  • Name: SH3 and PX domain containing protein 2A (Adapter protein TKS5) (Five SH3 domain containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
  • Length: 1133  
  • Mass: 125289
  • Tissue specificity: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO
• Sequence:

  MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFL
  PGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAE
  SPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNG
  TRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNL
  EGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK
  KEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVE
  VEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPP
  APPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQR
  ARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEK
  NAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCP
  RAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITL
  PATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE
  QPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQV
  AVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQR
  NSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVP
  SNYLEKKN

• Structural information:
  • Protein Domains: (4..12-)
    (/note="PX-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00147-)
    (166..22-)
    (/note="SH3-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
    (266..32-)
    (/note="SH3-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192-)
    (4-)
  • Interpro: IPR001683  IPR036871  IPR036028  IPR001452  IPR037961   IPR034917  IPR035450  IPR035452  IPR035449  IPR035453  IPR035454  
  • Prosite: PS50195 PS50002
  • CDD: cd06888 cd12074 cd12077 cd12079 cd12019 cd12020
  • PDB: 2DNU 2EGA 2EGC 2EKH
  • PDBsum: 2DNU 2EGA 2EGC 2EKH
  • STRING: ENSP00000348215
• Other Databases: GeneCards:  SH3PXD2A  Malacards:  SH3PXD2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0072675	osteoclast fusion	IMP	biological process
GO:0006801	superoxide metabolic process	IBA	biological process
GO:0032266	phosphatidylinositol-3-phosphate binding	IBA	molecular function
GO:0016176	superoxide-generating NADPH oxidase activator activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0002102	podosome	IEA	cellular component
GO:0010314	phosphatidylinositol-5-phosphate binding	IEA	molecular function
GO:0070273	phosphatidylinositol-4-phosphate binding	IEA	molecular function
GO:0001701	in utero embryonic development	IEA	biological process
GO:0002020	protease binding	IEA	molecular function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0032266	phosphatidylinositol-3-phosphate binding	IEA	molecular function
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	IEA	molecular function
GO:0072593	reactive oxygen species metabolic process	IEA	biological process
GO:0002102	podosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0043085	positive regulation of catalytic activity	IEA	biological process
GO:0006801	superoxide metabolic process	IDA	biological process
GO:0002102	podosome	IDA	cellular component
GO:0006801	superoxide metabolic process	IMP	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq