• Gene id: 9636

Gene Summary

• Gene Symbol: ISG15   Gene   UCSC   Ensembl
• Aliases: G1P2, IFI15, IMD38, IP17, UCRP, hUCRP
• Gene name: ISG15 ubiquitin like modifier
• Alternate names: ubiquitin-like protein ISG15, interferon, alpha-inducible protein (clone IFI-15K), interferon-induced 17-kDa/15-kDa protein, interferon-stimulated protein, 15 kDa, ubiquitin cross-reactive protein,
• Gene location: 1p36.33 (1013496: 1014539)     Exons: 10     NC_000001.11
• Gene summary(Entrez): The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic ac
• OMIM: 147571

Protein Summary

• Protein general information: P05161  
  • Name: Ubiquitin like protein ISG15 (Interferon induced 15 kDa protein) (Interferon induced 17 kDa protein) (IP17) (Ubiquitin cross reactive protein) (hUCRP)
  • Length: 165  
  • Mass: 17888
  • Tissue specificity: Detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. Expressed in neutrophils, monocytes and lymphocytes. Enhanced expression seen in pancreatic adenocarcinoma, endometrial cancer, and bladder cancer,
• Sequence:

  MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVV
  DKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFM
  NLRLRGGGTEPGGRS

• Structural information:
  • Protein Domains: (2..7-)
    (/note="Ubiquitin-like-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00214-)
    (79..15-)
    (/note="Ubiquitin-like-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00214"-)
  • Interpro: IPR000626  IPR029071  IPR019956  
  • Prosite: PS50053
  • PDB: 1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA
  • PDBsum: 1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA
  • DIP: 29814
  • STRING: ENSP00000368699
• Other Databases: GeneCards:  ISG15  Malacards:  ISG15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032020	ISG15-protein conjugation	IDA	biological process
GO:0031625	ubiquitin protein ligase binding	IBA	molecular function
GO:0031386	protein tag	IBA	molecular function
GO:0032020	ISG15-protein conjugation	IBA	biological process
GO:0019941	modification-dependent protein catabolic process	IBA	biological process
GO:0016567	protein ubiquitination	IBA	NOT|biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0034340	response to type I interferon	IDA	biological process
GO:0031397	negative regulation of protein ubiquitination	IDA	biological process
GO:0005576	extracellular region	IDA	cellular component
GO:0032020	ISG15-protein conjugation	IDA	biological process
GO:0030501	positive regulation of bone mineralization	ISS	biological process
GO:0051607	defense response to virus	IMP	biological process
GO:0045071	negative regulation of viral genome replication	IMP	biological process
GO:0032649	regulation of interferon-gamma production	IMP	biological process
GO:0042742	defense response to bacterium	IMP	biological process
GO:0032020	ISG15-protein conjugation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0002376	immune system process	IEA	biological process
GO:0051607	defense response to virus	IEA	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0032480	negative regulation of type I interferon production	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0019985	translesion synthesis	TAS	biological process
GO:0060337	type I interferon signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042742	defense response to bacterium	IEA	biological process
GO:0032020	ISG15-protein conjugation	IEA	biological process
GO:0019941	modification-dependent protein catabolic process	IEA	biological process
GO:0051607	defense response to virus	IEA	biological process
GO:0045648	positive regulation of erythrocyte differentiation	IEA	biological process
GO:0031386	protein tag	IEA	molecular function
GO:0030501	positive regulation of bone mineralization	IEA	biological process
GO:0009617	response to bacterium	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0072643	interferon-gamma secretion	IDA	biological process
GO:0007229	integrin-mediated signaling pathway	IDA	biological process
GO:0072608	interleukin-10 secretion	IDA	biological process
GO:0005178	integrin binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05165	Human papillomavirus infection
hsa05169	Epstein-Barr virus infection
hsa04622	RIG-I-like receptor signaling pathway

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)